Alexei Vassilev Selected Research

LFM A13

1/2007	Anti-breast cancer activity of LFM-A13, a potent inhibitor of Polo-like kinase (PLK).
9/2003	The anti-leukemic Bruton's tyrosine kinase inhibitor alpha-cyano-beta-hydroxy-beta-methyl-N-(2,5-dibromophenyl) propenamide (LFM-A13) prevents fatal thromboembolism.
5/2002	In vivo pharmacokinetic features, toxicity profile, and chemosensitizing activity of alpha-cyano-beta-hydroxy-beta- methyl-N-(2,5-dibromophenyl)propenamide (LFM-A13), a novel antileukemic agent targeting Bruton's tyrosine kinase.

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Alexei Vassilev Research Topics

Disease

3	Neoplasms (Cancer) 11/2007 - 01/2007
1	Cellulitis 02/2008
1	Peritonitis 02/2008
1	Colitis 02/2008
1	Systemic Inflammatory Response Syndrome (Sepsis Syndrome) 02/2008
1	Inflammation (Inflammations) 02/2008
1	Breast Neoplasms (Breast Cancer) 01/2007
1	Glioblastoma (Glioblastoma Multiforme) 01/2007
1	Adenomatous Polyposis Coli (Familial Adenomatous Polyposis) 01/2007
1	Pulmonary Embolism 09/2003
1	Thromboembolism 09/2003
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 03/2003
1	Lymphoma (Lymphomas) 05/2002
1	Leukemia 05/2002

Drug/Important Bio-Agent (IBA)

3	WHI P131IBA 02/2008 - 03/2003
3	LFM A13IBA 01/2007 - 05/2002
2	Janus Kinase 3IBA 11/2007 - 01/2007
2	Phosphotransferases (Kinase)IBA 01/2007 - 01/2007
1	Biological ProductsIBA 02/2008
1	Gemcitabine FDA Link 01/2007
1	Paclitaxel (Taxol)FDA LinkGeneric 01/2007
1	ErbB Receptors (EGF Receptor)IBA 01/2007
1	Epidermal Growth Factor (EGF)IBA 01/2007
1	Tyrosine (L-Tyrosine)FDA Link 01/2007
1	Oncogene Proteins (Oncogene Protein)IBA 01/2007
1	GenisteinIBA 01/2007
1	Agammaglobulinaemia Tyrosine KinaseIBA 09/2003
1	Insulin (Novolin)FDA Link 03/2003
1	Janus KinasesIBA 03/2003
1	Vincristine (Oncovin)FDA LinkGeneric 05/2002
1	Methylprednisolone FDA LinkGeneric 05/2002
1	Asparaginase (Elspar)FDA Link 05/2002

Therapy/Procedure

1	Drug Therapy (Chemotherapy) 05/2002